Closest Casino Resorts near Destin, FLīy taking a short 1-2 hour drive west from Destin, you can access several extravagant casino resort complexes boasting hundreds of table games, thousands of slot machines, premier poker rooms, on-site sportsbooks, luxury spas, headline concerts and shows, and much more Vegas-style amenities. However, casino cruises, racinos, and tribal gaming facilities that offer certain casino-style games can be found in the greater North Florida and Florida panhandle area. To answer the question outright – there are currently no full casinos actually located within the city limits of Destin, FL.